Etudes en cours

Zengin G et al.
Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles.
J Pharm Biomed Anal. 2019 Jan 05, 162:225-233.

The genus Scrophularia has received much interest with regards to its traditional uses against eczema, psoriasis, and mastitis. Yet, the medicinal properties of some species still need to be scientifically validated. The present study was designed to investigate into the biological properties of various solvent extracts (ethyl acetate, methanol, and aqueous) of the roots and aerial parts of Scrophularia lucida based on its antioxidant, anti-inflammatory, and enzyme inhibitory activities (...)

Mei Q et al.
Associations between PTPN2 gene polymorphisms and psoriasis in Northeastern China.
Gene. 2019 Jan 10, 681:73-79.

Psoriasis is a chronic immune-mediated disease with a complex etiology involving various genetic and immunological factors as well as environmental factors. Psoriasis is thought to be mediated by T-cells polarized to a Th17 fate. PTPN2 encodes the T-cell protein tyrosine phosphatase, which acts as a negative regulator of the JAK/STAT signaling pathways downstream of cytokines and plays a prominent role in T-cell activation, signaling and/or effector function. To evaluate the association (...)

Singh S et al.
Genomic alterations driving psoriasis pathogenesis.
Gene. 2019 Jan 30, 683:61-71.

Psoriasis is an immune mediated inflammatory skin disease with complex etiology involving interplay between environmental and genetic risk factors as disease initiating event. Enhanced understanding on genetic risk factors, differentially expressed genes, deregulated proteins and pathway-targeted therapeutics have established multiple axis of psoriasis pathogenesis. So far, loci in 424 genes are reported to be associated with psoriasis alongside copy number variations and epigenetic (...)

Mueller RS.
Update on Allergen Immunotherapy.
Vet. Clin. North Am. Small Anim. Pract.. 2019 Jan , 49, (1):1-7.

Allergen immunotherapy has been used for many years in dogs and cats and is the only specific treatment of atopic dermatitis that changes the patho-mechanisms of disease by stimulating allergen tolerance. Subcutaneous administration of allergens is the most commonly used administration route, typically in increasing concentrations (induction period) followed by long-term injection of allergen extract (maintenance therapy). Rush protocols with an abbreviated induction period have been (...)

Santoro D.
Therapies in Canine Atopic Dermatitis: An Update.
Vet. Clin. North Am. Small Anim. Pract.. 2019 Jan , 49, (1):9-26.

Canine atopic dermatitis (AD) is one of the most common inflammatory skin diseases in dogs. The pathogenesis is complex and not completely understood. Many therapeutic options are available; however, because of cost, side effects, or a long lag phase, new compounds are constantly produced. This article provides a comprehensive review of the latest compounds for the treatment of canine AD. In addition, a brief review of new studies on conventional medications is provided. For a successful (...)

Shumaker AK.
Diagnosis and Treatment of Canine Acral Lick Dermatitis.
Vet. Clin. North Am. Small Anim. Pract.. 2019 Jan , 49, (1):105-123.

Acral lick dermatitis is a common, frustrating disease. It is characterized by incessant licking behavior resulting in raised, thickened, ulcerative plaques, most commonly affecting the lower extremities of dogs. Underlying primary diseases, such as allergic disorders (atopic dermatitis, food allergy, flea allergy), orthopedic or neurologic disorders, parasitic diseases (eg, demodicosis), infections (fungal, bacterial), neoplasia or psychogenic disorders (compulsive/obsessive-compulsive (...)