Introduction

Aleshaki JS et al.
Adherence and resource use among psoriasis patients treated with biologics.
Expert Rev Pharmacoecon Outcomes Res. 2018 Dec , 18, (6):609-617.

The emergence of immune-modulating drugs such as biologics has altered the treatment landscape for psoriasis. However, their use presents high financial costs to patients and healthcare systems. Patient demographic and socioeconomic status may influence adherence to biologic medications and usage of healthcare resources. Areas covered: We performed a systematic literature review to summarize the available evidence pertaining to biologic medication adherence and resource use. PubMed was (...)

Bissinger R et al.
Genetic deficiency of the tumor suppressor protein p53 influences erythrocyte survival.
Apoptosis. 2018 Dec , 23, (11-12):641-650.

The transcription factor p53 suppresses tumor growth by inducing nucleated cell apoptosis and cycle arrest. Because of its influence on primitive erythroid cell differentiation and survival, p53 is an important determinant of erythropoiesis. However, the impact of p53 on the fate of erythrocytes, cells lacking nucleus and mitochondria, during their post-maturation phase in the circulation remained elusive. Erythrocyte survival may be compromised by suicidal erythrocyte death or eryptosis, (...)

Bhattacharya M et al.
Therapeutic applications of zebrafish (Danio rerio) miRNAs linked with human diseases: A prospective review.
Gene. 2018 Dec 30, 679:202-211.

MicroRNAs (miRNAs) are the class of small, non-coding RNAs that are produced from precursor transcripts by subsequent processing steps mediated by members of the RNaseIII family, Dicer and Drosha protein within cell. The importance of zebrafish miRNAs in regulation of normal cellular development and support to various kinds of metabolism process. Although the zebrafish model provides a fundamental platform for the study of developmental biology but recent work with zebrafish model has (...)

Rea CJ et al.
Associations of Eczema Severity and Parent Knowledge With Child Quality of Life in a Pediatric Primary Care Population.
Clin Pediatr (Phila). 2018 Nov , 57, (13):1506-1514.

We investigated factors associated with quality of life (QOL) in children with eczema. We conducted a cross-sectional analysis of survey data from 224 parents of children with eczema attending a large, hospital-based pediatric clinic. Parents completed a validated eczema severity scale (Patient-Oriented Eczema Measure), a QOL scale (Infants' Dermatitis QOL Index or Children's Dermatology Life Quality Index), and a knowledge and understanding questionnaire. In adjusted multivariate analyses, (...)

Sharma G et al.
Probiotics as a Potential Immunomodulating Pharmabiotics in Allergic Diseases: Current Status and Future Prospects.
Allergy Asthma Immunol Res. 2018 Nov , 10, (6):575-590.

The prevalence of allergic disorders has dramatically increased over the past decade, particularly in developed countries. Apart from gastrointestinal disorders, neoplasia, genital and dermatological diseases , dysregulation of gut microbiota (dysbiosis) has also been found to be associated with increased risk of allergies. Probiotics are increasingly being employed to correct dysbiosis and, in turn, to modulate allergic diseases. However, several factors like strain variations and effector (...)

Park SH et al.
A novel pH-responsive hydrogel based on carboxymethyl cellulose/2-hydroxyethyl acrylate for transdermal delivery of naringenin.
Carbohydr Polym. 2018 Nov 15, 200:341-352.

In this study, a pH-responsive hydrogel (cl-CMC-g-pHEA), based on carboxymethyl cellulose/2-hydroxyethyl acrylate, was prepared. Its physicochemical properties and applicability as a transdermal delivery system for naringenin (NRG) were investigated. The hydrogel was synthesized via radical polymerization; its structure was analyzed by FT-IR and H NMR. The water loss amount was measured by using thermogravimetric analysis; a porous 3D network structure was confirmed by SEM. All hydrogels (...)