Psoriasis treatments may be used topically or systemically. We are going to consider the various topical and systemic therapies, their utilization strategies and the problems raised by the particular cases encountered most often.
Psoriasis treatment breaks down into two phases: the clearing phase and the maintenance phase. The aim of the clearing phase is to get rid of the lesions; the aim of the maintenance phase is to avoid relapses. In the clearing phase, effectiveness is the chief consideration; in the maintenance phase, tolerability and the convenience of the drugs become the main concern, since the skin lesions will have disappeared.
It is considered necessary to pursue maintenance therapy for about a year in order to hope for a lasting remission. This important point has never been validated by a clinical study. Such consideration lies on a number of factors: that relapse is usually observed swiftly if treatment is stopped at the end of the clearing phase; that the microcirculatory anomalies will persist for months after the clinical disappearance of the lesions; and that relapse usually begins on the spot of the old plaques as if the skin retained its memory of the inflammation for a long time, perhaps through the persistence of receptors enabling the inflammatory cells to adhere to the endothelial cells.
However, around 30% of patients benefit from prolonged remission, being able to pass the one-year mark after a properly conducted clearing phase, as it has been demonstrated with PUVA therapy and cyclosporine. This prolonged remission seems to be more frequent when the clearing phase is halted progressively rather than suddenly.
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Recent publications on Psoriasis and Atopic Dermatitis
on Psoriasis
Psoriasis image representation using patch-based dictionary learning for erythema severity scoring.
Comput Med Imaging Graph.
2018 Jun , 66:44-55.
Psoriasis is a chronic skin disease which can be life-threatening. Accurate severity scoring helps dermatologists to decide on the treatment. In this paper, we present a semi-supervised computer-aided system for automatic erythema severity scoring in psoriasis images. Firstly, the unsupervised stage includes a novel image representation method. We construct a dictionary, which is then used in the sparse representation for local feature extraction. To acquire the final image representation (...)
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Hydroxyethyl methacrylate grafted carboxy methyl tamarind (CMT-g-HEMA) polysaccharide based matrix as a suitable scaffold for skin tissue engineering.
Carbohydr Polym.
2018 Jun 01, 189:87-98.
Patho-physiologies related to skin are diverse in nature such as burns, skin ulcers, atopic dermatitis, psoriasis etc. which impose severe bio-medical problems and thus enforce requirement of new and healthy skin prepared through tissues engineering methodologies. However, fully functional and biodegradable matrix for attachment, growth, proliferation and differentiation of the relevant cells is not available. In the present study, we introduce a set of hydrogels synthesized by (...)
see on pubmed
Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells.
Redox Rep..
2018 Dec , 23, (1):130-135.
Psoriasis is a common, chronic, inflammatory skin disease that affects 2%-4% of the global population. Recent studies have shown that increased oxidative stress (OS) and T-cell abnormalities are central to the pathogenesis of this disease. The resulting reactive oxygen species (ROS) induces proliferation and differentiation of Th17/Th1/Th22 cells and inhibits the anti-inflammatory activities of regulatory T lymphocytes (Treg). Subsequent secretions of inflammatory cytokines, such as (...)
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on Atopic Dermatitis
Rhododendron album Blume extract inhibits TNF-α/IFN-γ-induced chemokine production via blockade of NF-κB and JAK/STAT activation in human epidermal keratinocytes.
Int. J. Mol. Med..
2018 Jun , 41, (6):3642-3652.
Rhododendron album Blume (RA) has traditionally been used as an herbal medicine and is considered to have anti‑inflammatory properties. It is a well‑known medicine for treatment of allergic or atopic diseases. In the present study, the biological effects of an RA methanol extract (RAME) on inflammation were investigated in tumor necrosis factor‑α (TNF‑α)/interferon‑γ (IFN‑γ)‑stimulated human keratinocytes. The present study aimed to investigate the potential mechanisms by which RAME inhibited (...)
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Hydroxyethyl methacrylate grafted carboxy methyl tamarind (CMT-g-HEMA) polysaccharide based matrix as a suitable scaffold for skin tissue engineering.
Carbohydr Polym.
2018 Jun 01, 189:87-98.
Patho-physiologies related to skin are diverse in nature such as burns, skin ulcers, atopic dermatitis, psoriasis etc. which impose severe bio-medical problems and thus enforce requirement of new and healthy skin prepared through tissues engineering methodologies. However, fully functional and biodegradable matrix for attachment, growth, proliferation and differentiation of the relevant cells is not available. In the present study, we introduce a set of hydrogels synthesized by (...)
see on pubmed
Identification of pyruvate kinase as a novel allergen in whiteleg shrimp (Litopenaeus vannamei) by specific-IgE present in patients with shrimp allergy.
Food Chem.
2018 Aug 30, 258:359-365.
Food allergy is one of the most important health issues worldwide. In Taiwan, current literature suggests shrimps and crabs are the most common causes of food allergy, and are frequently associated with acute allergic reactions such as urticaria, atopic dermatitis, and asthma. However, knowledge regarding the shrimp allergens remains limited. Thus, there is an urgent need to establish comprehensive information for elucidating underlying triggers for food allergy. In this study, whiteleg (...)
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