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Psoriasis: a non-inhibited normal healing process

The assault on the stratum corneum in normal human skin causes a stream of events ending in hyperproliferation of the basement membrane cells. Among these events, the activation of subcorneal proteases, rapidly inhibited in normal subjects, is inhibited much later in psoriatics. When the attack on the stratum corneum culminates in Köebner’s phenomenon, this protease activation carries on until a clinically and histologically typical psoriasis plaque appears. These subcorneal proteases involved in the healing process are permanently activated in all psoriasis plaques. As such, the process takes place as if psoriasis stemmed from an inhibition defect in epidermal healing following an attack, hence leading to a permanent proliferation maintained secondarily by the inflammation.

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