SPIN 2019 Congress

van de Kerkhof PC.
Branching immune pathways in psoriasis and its significance for disease severity assessment.
J Dermatolog Treat. 2018 Nov , 29, (7):641-642.

Kang NW et al.
Curcumin-loaded lipid-hybridized cellulose nanofiber film ameliorates imiquimod-induced psoriasis-like dermatitis in mice.
Biomaterials. 2018 Nov , 182:245-258.

Cellulose nanofiber (CNF) is an attractive biomaterial given its film-forming properties, excellent mechanical properties and biocompatibility. Herein, CNF film was prepared as a topical drug delivery system by hybridizing curcumin (Cur)-loaded nanostructured lipid carriers (NLCs). NLCs with a mean diameter of ≈500 nm were fabricated by using a solvent diffusion method. The lipid composition of the NLCs was optimized based on the efficiency of Cur delivery to the artificial skin and (...)

Lai R et al.
Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells.
Redox Rep.. 2018 Dec , 23, (1):130-135.

Psoriasis is a common, chronic, inflammatory skin disease that affects 2%-4% of the global population. Recent studies have shown that increased oxidative stress (OS) and T-cell abnormalities are central to the pathogenesis of this disease. The resulting reactive oxygen species (ROS) induces proliferation and differentiation of Th17/Th1/Th22 cells and inhibits the anti-inflammatory activities of regulatory T lymphocytes (Treg). Subsequent secretions of inflammatory cytokines, such as (...)

Bakker DS et al.
Lymphopenia in atopic dermatitis patients treated with oral immunosuppressive drugs.
J Dermatolog Treat. 2018 Nov , 29, (7):682-687.

Oral immunosuppressive drugs are commonly used in the treatment of atopic dermatitis (AD). In patients with autoimmune- and rheumatic diseases, these drugs have been associated with lymphopenia. Lymphopenia is related to an increased risk of opportunistic infections. The incidence of lymphopenia in patients with AD treated with oral immunosuppressive drugs is yet unknown.

Hong SH et al.
Oral administration of Cervus nippon mantchuricus extract suppresses 2,4-dinitrochlorobenzene-induced atopic dermatitis in BALB/c mice and inflammatory effects in mast cells.
Int. J. Mol. Med.. 2018 Nov , 42, (5):2961-2971.

Cervus nippon mantchuricus extract, known as nok‑gol (NGE) in Korean, is useful for the treatment of various inflammatory diseases, including bone resorption and neutropenia. However, NGE has not been widely investigated, and its efficacy and safety remain to be fully elucidated. In the present study, histological analysis, blood analysis, reverse transcription‑semi-quantitative polymerase chain reaction analysis and enzyme‑linked immunosorbent assays were performed to verify the inhibitory (...)

Park SH et al.
A novel pH-responsive hydrogel based on carboxymethyl cellulose/2-hydroxyethyl acrylate for transdermal delivery of naringenin.
Carbohydr Polym. 2018 Nov 15, 200:341-352.

In this study, a pH-responsive hydrogel (cl-CMC-g-pHEA), based on carboxymethyl cellulose/2-hydroxyethyl acrylate, was prepared. Its physicochemical properties and applicability as a transdermal delivery system for naringenin (NRG) were investigated. The hydrogel was synthesized via radical polymerization; its structure was analyzed by FT-IR and H NMR. The water loss amount was measured by using thermogravimetric analysis; a porous 3D network structure was confirmed by SEM. All hydrogels (...)