Crisis situations upset the theoretical therapeutic strategy, which ranges from topical treatments to systemic treatments, and from treatments with the fewest side effects to treatments with potentially more serious side effects.
It is all about facing up to an urgent request on the part of the patient: holidays, wedding etc. It is about facing up to the stark psychological suffering by a patient whose relationship with his chronic illness swings back and forth. In a patient whose treatment is well balanced, it is about facing up to an abrupt attack of the disease, triggered by an external event: stress, contact eczema, toxidermia, etc., and that will always need to be tracked down and identified. Of the systemic treatments, topical corticosteroids are the best crisis therapy known to date, being fully well aware that once topical corticotherapy has been started, it will be necessary to devote some thought to its relay, and to the means of avoiding a rebound or a self-perpetuation of the disease. Among the general treatments, phototherapy or PUVA therapy are excellent crisis therapies, when usable. Cyclosporine is also an excellent crisis treatment. Methotrexate acts more slowly and retinoids far more slowly.
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Recent publications on Psoriasis and Atopic Dermatitis
on Psoriasis
Total glucosides of paeony: A review of its phytochemistry, role in autoimmune diseases, and mechanisms of action.
J Ethnopharmacol.
2020 Aug 10, 258:112913.
Paeoniae Radix Alba (PRA, called baishao in China), the root of Paeonia lactiflora Pall., has shown a rich medicinal value for more than 2000 years. PRA is used in local medicine and traditional medicine for autoimmune diseases associated with inflammation. At present, total glucosides of paeony (TGP), the main active ingredient of PRA, has been developed into a preparation for the treatment of autoimmune diseases, as TGP exhibits the effect of regulating immunity, anti-inflammatory, and (...)
see on pubmed
Immobilization of papain enzyme on a hybrid support containing zinc oxide nanoparticles and chitosan for clinical applications.
Carbohydr Polym.
2020 Sep 01, 243:116498.
A new hybrid bionanomaterial composed of zinc oxide nanoparticles (ZnO NPs) and chitosan was constructed after enzymatic immobilization of papain for biomedical applications. In this work, we report the preparation and characterization steps of this bionanomaterial and its biocompatibility in vitro. The properties of the immobilized papain system were investigated by transmission electron microscopy, zeta potential, DLS, UV-vis absorption spectroscopy, FTIR spectroscopy, and X-ray (...)
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Tackling the various classes of nano-therapeutics employed in topical therapy of psoriasis.
Drug Deliv.
2020 Dec , 27, (1):662-680.
Psoriasis is a dermatological chronic skin condition with underlying autoimmune etiology. It deeply affects patients' quality of life. Therefore, it was an interesting target for researchers throughout the past years. Conventionally, the treatment options include anti-inflammatory agents, immune suppressants, biologic treatment, and phototherapy. Nanotechnology offers promising characteristics that allow for tailoring a drug carrier to achieve dermal targeting, improved efficacy and (...)
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on Atopic Dermatitis
The clinical impact of cross-reactions between allergens on allergic skin diseases.
Curr Opin Allergy Clin Immunol.
2020 Aug , 20, (4):374-380.
The route of allergen sensing via the skin appears to influence the immune system towards mounting a type 2 response, especially in genetically predisposed individuals. Allergens recognized this way may derive from microbial, animal, food, or other plant sources and trigger atopic dermatitis. Allergens can be grouped into families depending on their structure and function, harboring significant structural and sequence similarities. Cross-reactivity between allergens is believed to arise as (...)
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Spectral diagnosis of health hazardous toxins in face foundation powders using laser induced breakdown spectroscopy and inductively coupled plasma-optical emission spectroscopy (ICP-OES).
Talanta.
2020 Sep 01, 217:121007.
In this work, we applied laser-induced breakdown spectroscopy (LIBS) to estimate the amount of toxic heavy metals (Pb, Cr, Ni) in five different brands of face foundation powders available in the local market using standard calibration curve (CC)-LIBS approach. These samples contain toxic elements like lead, chromium, nickel which are highly carcinogens to cause eczematous and atopic dermatitis. The strongest atomic transition lines of lead (405.7 line), chromium (425.4 nm line), and nickel (...)
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Update on canine filaggrin: a review.
Combarros D et al.
Update on canine filaggrin: a review.
Vet Q.
2020 Dec , 40, (1):162-168.
Human filaggrin (FLG) plays a key role in epidermal barrier function, and loss-of-function mutations of its gene are primarily responsible for the development of human atopic dermatitis (AD). FLG expression is also reduced in the epidermis of atopic patients, due to the transcriptional effect of Th2 type cytokines. Canine atopic dermatitis (CAD) is a prevalent skin disease that shares many clinical and pathogenic features with its human homologue. The aim of this review is discuss current (...)
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