Psoriasis is a model disease in dermatology. It is a common disease that affects at least 2 to 3% of the population in the European Union. As a matter of fact, more than half of patients do not take care of themselves, either because the inefficacy of the treatments available discourages them or because such treatments strike them as being more restrictive than psoriasis itself, or because they are in remission.
It is an illness only present in humans, characterized by an excessive reaction of the skin to attacks from the internal and external environment, most often of genetic origin. These attacks can be immunologic, mechanic, metabolic, drug-induced or psychological. As such, understanding the physiopathology of psoriasis calls for a greater understanding of the interactions between the skin cells on the one hand and the interactions between the skin and the central nervous system (CNS) on the other. This excessive reaction is characterized by epidermal proliferation combined with incomplete terminal differentiation, as well as an excessive inflammatory response responsible for the chronic nature of the lesions. The way to understand psoriasis is to reach therefore a better appreciation of the messages that enable the skin cells to initiate an inflammatory response, and a better understanding of the way in which the inflammatory cells, responsible for innate and acquired immune responses, are capable of bringing about proliferation and abnormal epidermal differentiation. Taking an interest in psoriasis is thus taking an interest in all facets of skin physiology and in all the ways the skin reacts to environmental aggressions.
psoriasis care differs between countries. It is important to plan psoriasis care
together with the patient associations. Psoriasis day care centres have become
increasingly common, especially in Scandinavia
in recent years.|auteur193]
For over thirty years now, more than 300 publications endeavour to explore each year one aspect or another of psoriasis from a clinical, epidemiological, physiopathological or therapeutic point of view. There is no new technique for observing the skin that has not been immediately applied to the study of psoriasis—which is a privileged mirror of the progresses made in dermatology. Nor has psoriasis remained untouched by whims of fashion, all kind of scenarios having been suggested to explain it, from a scarring disease to an autoimmune illness, or even a genetic or psychosomatic disorder.
Psoriasis is at the origin of a medical revolution necessary to complete and enhance the effectiveness of evidence-based medicine; it is the so-called “patient-based medicine”. This concept refers to the development of techniques aiming to apply the scientific evidence-based medicine knowledge, built by studying populations, to an individual and specific patient.
Psoriasis is very rarely life threatening. Conversely, it is a disease that does affect, sometimes very severely, the quality of life. The patient is the judge of his or her quality of life, and it is, therefore, up to the patient, not to the doctor, to gauge the severity of psoriasis. This is a key point to decide the best therapeutic strategy. Psoriasis cannot be treated then without placing the patient, not the illness, at the centre of therapeutic negotiations. The 20th century has witnessed boundless efforts concentrating in the disease; the 21st century witnesses the development of medical techniques that allow the patient, in all its complexity, to be placed at the centre of therapeutic efforts. This revolution began in dermatology, revolving around psoriasis, and is spreading progressively to all chronic disorders and all disciplines.
It is difficult not to be passionate about psoriasis and those suffering from it. The aim of this book is to convey the passion of different experts on psoriasis in the world. The chosen strategy has been to ask experts in the world to react to this position paper. This way we hope to avoid the two scourges of therapy, recipes and one-way thought, by complementing and relativizing each chapter with the views of different experts. Above all, the goal of this book is to initiate a dialogue with the reader.
Professor Louis DUBERTRET
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- 2018/02/222nd National Meeting of the Egyptian Society for Psoriasis
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News from medical groups
- 2018/04/183rd Turkish National Psoriasis Symposium
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- 2017/02/02Works of the 1st Senegalese Psoriasis Day published!
- 2016/07/29Swiss S1 Guidelines for Systemic treatment of psoriasis vulgaris
News from patients associations
- 2017/02/08France Psoriasis - 2016 World Psoriasis Day
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- 2015/08/04Epidermia Greece: a new partner association of PIN
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- 2015/04/09AEPSO Argentina launches digital map to find people with psoriasis in the country
Recent publications on Psoriasis and Atopic Dermatitis
Integrated analysis of gene expression profiles identifies transcription factors potentially involved in psoriasis pathogenesis.
J. Cell. Biochem.. 2019 Aug , 120, (8):12582-12594.
Psoriasis is a common inflammatory skin disease mediated by cells and molecules in both the innate and adaptive immune systems. Recently, gene expression profile analysis revealed a large set of immune-related differentially expressed genes (DEGs) in psoriasis. However, the associations between these DEGs and their transcriptional regulation mechanisms have not been completely elucidated. In this study, several psoriasis Gene Expression Omnibus data sets were systematically analyzed using (...)see on pubmed
Models of human psoriasis: Zebrafish the newly appointed player.
Dev. Comp. Immunol.. 2019 Aug , 97:76-87.
Psoriasis is a human chronic, immune disease with severe cutaneous and systemic manifestations. Its prevalence, among the world population, highly varies with ethnicity and geography, but not sex from remarkable low levels in Asia to 2.3% in Spain, or an impressive 11.5% in Norway. The pathogenesis of psoriasis derives from complex genetic and environmental interactions, which creates aberrant crosstalk between keratinocytes and variated immune cell, resulting in open amplified inflammatory (...)see on pubmed
A vivid cytokines interaction model on psoriasis with the effect of impulse biologic (TNF-α inhibitor) therapy.
J. Theor. Biol.. 2019 Aug 07, 474:63-77.
Psoriasis is a chronic skin condition that produces plaques of condensed, scaling skin due to excessively rapid proliferation of keratinocytes. During the disease progression, keratinocyte proliferation is influenced by many immune cells and cytokines. This article deals with a five dimensional deterministic model, which has been derived using quasi-steady-state approximation for describing the dynamics of psoriasis in various cytokines environment. Equilibrium analysis of the system shows (...)see on pubmed
Synthesis of chitosan derivatives with organoselenium and organosulfur compounds: Characterization, antimicrobial properties and application as biomaterials.
Carbohydr Polym. 2019 Sep 01, 219:240-250.
In this study, Schiff bases of chitosan (CS) were synthesized using citronellal, citral, and their derivatives containing selenium and sulfur. Organoselenium and organosulfur compounds show attractive biological and pharmaceutical activities, which can be beneficial to CS-based materials. From the characterization analyses, it was found that the CS-derivatives containing organoselenium and organosulfur compounds exhibited the highest conversion degrees (23 and 28%). Biological assays were (...)see on pubmed
Skin inflammation induced by ambient particulate matter in China.
Sci. Total Environ.. 2019 Sep 10, 682:364-373.
Most published studies on particulate matter (PM) concerning PM and PM have focused on PM-induced effects on the respiratory system (particularly lung) and cardiovascular system effects. However, epidemiological and mechanistic studies suggest that PM and PM also affects the skin, which is a key health issue. In this study, we first reviewed the current status of PM and PM in China, including relevant regulations, concentration levels, chemical components, and emission sources. Next, we (...)see on pubmed
Effect of cinnamamides on atopic dermatitis through regulation of IL-4 in CD4 cells.
J Enzyme Inhib Med Chem. 2019 Dec , 34, (1):613-619.
This study aimed to evaluate the effects of cinnamamides on atopic dermatitis (AD) and the mechanisms underlying these effects. To this end, the actions of two cinnamamides, (E)-3-(4-hydroxyphenyl)-N-phenylethyl acrylamide (NCT) and N-trans-coumaroyltyramine (NCPA), were determined on AD by orally administering them to mice. Oral administration of the cinnamamides ameliorated the increase in epidermal and dermal thickness as well as mast cell infiltration. Cinnamamides suppressed serum (...)see on pubmed