The plethora of triggering events, of physiopathological pathways and of clinical manifestations turns attention from the disease to the patient, who finally realizes his or her own psoriasis.
The patient must be made aware that psoriasis is not contagious, that it does not put life at risk, that it is an excessive skin reaction—often genetically programmed—to environmental factors which are important to identify. Psoriasis can reveal itself at any time of life. Whatever the situation, it will be possible to treat it, to relieve it, but no definitive cure can be promised. When explaining to a patient that there is no cure, one needs to be mindful that he will generally understand that he cannot be treated— which is something very different though. Equally, the patient must realize that psoriasis is “the skin regenerating too quickly” and that any drug, with its very different mechanisms, will only slow down this cutaneous regeneration. That is why, if the treatment is halted as soon as the skin has regained its normal appearance, the patient risks a very rapid relapse, or even a rebound. These explanations will allow the patient to understand that the fundamental is to carry on treatments, even once the skin appears to have become normal again, in order to give the skin’s natural anti-inflammatory mechanisms time to re-establish themselves.
The acceleration in epidermal regeneration caused by various attacks and, more particularly, by scratching, must be properly understood by the patient, given the impossibility of getting rid of a psoriasis plaque if it is regularly scratched. Finally, the patient must understand that although psoriasis is not endangering his life, it may be impairing his quality of life, therein lying the gravity of the illness. He must therefore learn, step by step, with the help of his dermatologist and GP, to manage all the aspects of his way of life leading to psoriasis flares on his hyperreactive skin. He must understand that, beyond the discomfort engendered by the disease and its treatment, the aim is to succeed in finding a better quality of life.
[|I very much enjoyed patient information issues, as we have for too long treated psoriasis as a trivial disorder. As mentioned by Professor Dubertret in his initial paragraphs at the end of his historical overview, time needs to be spent with each and every patient utilizing literature from patient organizations, eg National Psoriasis Foundation and similar national foundations, to educate patients. Psoriasis being a lifelong disease requires time and patience from physicians, which in the 21st century is frequently not readily available.|auteur215]
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Recent publications on Psoriasis and Atopic Dermatitis
on Psoriasis
Discovery of benzo[f]pyrido[4,3-b][1,4]oxazepin-10-one derivatives as orally available bromodomain and extra-terminal domain (BET) inhibitors with efficacy in an in vivo psoriatic animal model.
Bioorg Med Chem.
2021 Mar 15, 34:116015.
Bromodomain and extra-terminal domain (BET) protein plays an important role in epigenetic regulation, and the regulation of disruption contributes to the pathogenesis of cancer and inflammatory disease. With the goal of discovering novel BET inhibitors, especially BRD4 inhibitors, we designed and synthesized several compounds starting from our previously reported pyrido-benzodiazepinone derivative 4 to enhance BRD4 inhibitory activity while avoiding hERG inhibition. Molecular docking (...)
see on pubmed
Clinical trait-connected network analysis reveals transcriptional markers of active psoriasis treatment with Liangxue-Jiedu decoction.
J Ethnopharmacol.
2021 Mar 25, 268:113551.
Psoriasis is a complex recurrent inflammatory skin disease with different pathological changes in different stages. Psoriasis in its active stage, which is comparable to the blood-heat type in traditional Chinese medicine (TCM), has been treated by Liangxue Jiedu Decoction (LJD) in TCM for decades, with proven efficacy. According to TCM theories, LJD has the function of removing heat and pathogenic factors from the (...)
see on pubmed
Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways.
Bioengineered.
2021 Dec , 12, (1):183-195.
Psoriasis is a chronic inflammatory skin disease that affects approximately 2% of worldwide population, and causing long-term troubles to the patients. Therefore, it is urgent to develop safe and effective therapeutic drugs. Catalpol is a natural iridoid glucoside, that has several remarkable pharmacological effects, however, whether catalpol can alleviated psoriasis has not been explored. The goal of the present work is to study the role of catalpol in psoriasis in vivo and in vitro. (...)
see on pubmed
on Atopic Dermatitis
Psychiatric and Nonpsychiatric Comorbidities Among Children With ADHD: An Exploratory Analysis of Nationwide Claims Data in Germany.
J Atten Disord.
2021 Apr , 25, (6):874-884.
This study examined the full spectrum of comorbid disorders in all statutory-health-insured children aged 5 to 14 years with ADHD in 2017 by using nationwide claims data in Germany. Children with ADHD ( = 258,662) were compared for the presence of 864 comorbid diseases with a control group matched by gender, age, and region of residence ( = 2,327,958). Among others, metabolic disorders (odds ratio [OR] = 9.18; 95% confidence interval [CI] = [8.43, 9.99]), viral pneumonia (OR = 4.95; 95% (...)
see on pubmed
Qingxue jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-κB signaling pathways.
J Ethnopharmacol.
2021 Apr 24, 270:113773.
Qingxue jiedu Formulation (QF) is composed of two classic prescriptions which have been clinically used for more than 5 centuries and appropriately modified through basic theory of traditional Chinese medicine for treating various skin inflammation such as atopic dermatitis (AD), acute dermatitis and rash. Although QF possesses a prominent clinical therapeutic effect, seldom pharmacological studies on its anti-AD activity are (...)
see on pubmed
Methicillin-resistant from infected skin lesions present several virulence genes and are associated with the CC30 in Brazilian children with atopic dermatitis.
Virulence.
2021 Dec , 12, (1):260-269.
Atopic dermatitis (AD) is a chronic inflammatory skin disease and colonization by may affect up to 100% of these patients. Virulent and resistant isolates can worsen AD patient clinical condition and jeopardize the treatment. We aimed to detect virulence genes and to evaluate the biofilm production of isolates from infected skin lesions of children with AD. Methicillin resistance was detected by phenotypic and molecular tests and the virulence genes were detected by PCR. Biofilm formation (...)
see on pubmed