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SPIN is currently conducting a study on "Current practice of phototherapy in psoriasis: a worldwide survey among dermatologists".
Phototherapy is one the most commonly used systemic therapies for psoriasis. Despite its widespread use in psoriasis therapy, dermatologists’ practice regarding the use of phototherapy has not been investigated on global scale. As such, the main objective of this study is to evaluate the real life use of phototherapy for psoriasis treatment in the dermatological community worldwide.
This project is led by Lajos Kemeny and Rolland Gyulai (Hungary) on behalf of SPIN, with the help of a steering committee including Luigi Naldi (Italy), José Manuel Carrascosa (Spain), Nejib Doss (Tunisia), Peter van de Kerkhof (The Netherlands) and Adrian Tanew (Austria).
A worldwide survey is being carried in 2016-2017. We will keep you updated!
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Latin American Clinical Practice Guidelines on the Systemic Treatment of Psoriasis
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Recent publications on Psoriasis and Atopic Dermatitis
on Psoriasis
Uncovering the mechanism of Jueyin granules in the treatment of psoriasis using network pharmacology.
J Ethnopharmacol.
2020 Nov 15, 262:113214.
Our clinical practice demonstrated that Jueyin granules (JYG) benefit patients with mild to moderate psoriasis vulgaris without apparent adverse effects. JYG have been shown to inhibit epidermal proliferation in an imiquimod (IMQ)-induced psoriasis-like mouse model, as well as keratinocyte proliferation. Moreover, JYG causes no acute or chronic toxicity in animal models. However, its related molecular mechanism has still not been (...)
see on pubmed
Tackling the various classes of nano-therapeutics employed in topical therapy of psoriasis.
Drug Deliv.
2020 Dec , 27, (1):662-680.
Psoriasis is a dermatological chronic skin condition with underlying autoimmune etiology. It deeply affects patients' quality of life. Therefore, it was an interesting target for researchers throughout the past years. Conventionally, the treatment options include anti-inflammatory agents, immune suppressants, biologic treatment, and phototherapy. Nanotechnology offers promising characteristics that allow for tailoring a drug carrier to achieve dermal targeting, improved efficacy and (...)
see on pubmed
In silico data mining of large-scale databases for the virtual screening of human interleukin-2 inhibitors.
Acta Pharm.
2021 Mar 01, 71, (1):33-56.
Interleukin-2 (IL-2) is involved in the activation and differentiation of T-helper cells. Uncontrolled activated T cells play a key role in the pathophysiology by stimulating inflammation and autoimmune diseases like arthritis, psoriasis and Crohn's disease. T cells activation can be suppressed either by preventing IL-2 production or blocking the IL-2 interaction with its receptor. Hence, IL-2 is now emerging as a target for novel therapeutic approaches in several autoimmune disorders. This (...)
see on pubmed
on Atopic Dermatitis
Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps.
Allergy Asthma Immunol Res.
2020 Nov , 12, (6):980-993.
Recent studies have revealed the pathogenic role of interleukin (IL)-22 in atopic dermatitis and asthma. However, little is known about the role of IL-22 in the pathophysiology of chronic rhinosinusitis with nasal polyps. We aimed to investigate the expression of IL-22 and its pathogenic function in type 2 immune reactions of nasal polyps (NP).
see on pubmed
Facial Redness in Atopic Dermatitis Patients Treated With Dupilumab: A Case Series.
Seok SH et al.
Facial Redness in Atopic Dermatitis Patients Treated With Dupilumab: A Case Series.
Allergy Asthma Immunol Res.
2020 Nov , 12, (6):1063-1065.
Update on canine filaggrin: a review.
Combarros D et al.
Update on canine filaggrin: a review.
Vet Q.
2020 Dec , 40, (1):162-168.
Human filaggrin (FLG) plays a key role in epidermal barrier function, and loss-of-function mutations of its gene are primarily responsible for the development of human atopic dermatitis (AD). FLG expression is also reduced in the epidermis of atopic patients, due to the transcriptional effect of Th2 type cytokines. Canine atopic dermatitis (CAD) is a prevalent skin disease that shares many clinical and pathogenic features with its human homologue. The aim of this review is discuss current (...)
see on pubmed
