Former Foundation René Touraine’s president Louis Dubertret explain what we should not think about psoriasis so as to better deal with it.
Former Foundation René Touraine’s president Louis Dubertret explain what we should not think about psoriasis so as to better deal with it.
Is psoriasis contagious ?
No. For instance, you can go without any risk to the swimming pool when your suffer from psoriasis. On the contrary, skins affected by psoriasis contain much more anti-infectious molecules than a normal skin. The risk is consequently lower.
Is psoriasis hereditary ?
This is a frequent question as psoriasis is a genetical disease. However, the transmission does not occur in a mathematical way involving one specific gene, but because of predisposition factors. A similar situation arises when a mother suffers from hay fever. Her children are likely to develop this disease, but nothing is statistically predictable. This concern about the children often grows in a case of severe psoriasis. It has to be reminded that when you mix your genes with those of another parent who is not affected by the disease, your children can only have, at worst, a more moderate form of psoriasis. Also, treatments are becoming increasingly efficient, which is a opportunity for us to stop perceiving psoriasis as a curse passed on from generation to generation.
If the cure is not working well, do I have to see another doctor ?
As the symptoms of psoriasis differ for each individual, the patients benefits from a priceless insight giving them information a doctor cannot know. Any patient willing to improve their condition have to communicate consistently about the evolution of their disease in order to enable their doctor to adjust the treatment progressively. Hence, it is a mistake to change your physician since it will make you start from scratch. Thus, it seems better to be patient enough to explain regularly to your doctor why you still are dissatisfied with your current treatment, so that he or she eventually finds the ideal one. This is all the more significant as no pratictioner can have an exhaustive knowledge, especially in the case of a disease that flares up differently for each patient.
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Recent publications on Psoriasis and Atopic Dermatitis
on Psoriasis
Integrated analysis of gene expression profiles identifies transcription factors potentially involved in psoriasis pathogenesis.
J. Cell. Biochem..
2019 Aug , 120, (8):12582-12594.
Psoriasis is a common inflammatory skin disease mediated by cells and molecules in both the innate and adaptive immune systems. Recently, gene expression profile analysis revealed a large set of immune-related differentially expressed genes (DEGs) in psoriasis. However, the associations between these DEGs and their transcriptional regulation mechanisms have not been completely elucidated. In this study, several psoriasis Gene Expression Omnibus data sets were systematically analyzed using (...)
see on pubmed
Models of human psoriasis: Zebrafish the newly appointed player.
Martínez-Navarro FJ et al.
Models of human psoriasis: Zebrafish the newly appointed player.
Dev. Comp. Immunol..
2019 Aug , 97:76-87.
Psoriasis is a human chronic, immune disease with severe cutaneous and systemic manifestations. Its prevalence, among the world population, highly varies with ethnicity and geography, but not sex from remarkable low levels in Asia to 2.3% in Spain, or an impressive 11.5% in Norway. The pathogenesis of psoriasis derives from complex genetic and environmental interactions, which creates aberrant crosstalk between keratinocytes and variated immune cell, resulting in open amplified inflammatory (...)
see on pubmed
A vivid cytokines interaction model on psoriasis with the effect of impulse biologic (TNF-α inhibitor) therapy.
J. Theor. Biol..
2019 Aug 07, 474:63-77.
Psoriasis is a chronic skin condition that produces plaques of condensed, scaling skin due to excessively rapid proliferation of keratinocytes. During the disease progression, keratinocyte proliferation is influenced by many immune cells and cytokines. This article deals with a five dimensional deterministic model, which has been derived using quasi-steady-state approximation for describing the dynamics of psoriasis in various cytokines environment. Equilibrium analysis of the system shows (...)
see on pubmed
on Atopic Dermatitis
Prenatal perfluorooctanoic acid exposure is associated with early onset atopic dermatitis in 5-year-old children.
Chemosphere.
2019 Sep , 231:25-31.
Atopic dermatitis (AD) is the most common childhood skin disease and the first step of atopic march. Perfluoroalkyl substance (PFAS) exposure is associated with atopic diseases, including AD. However, whether PFAS exposure is related to earlier AD onset remains unclear. We aimed to investigate the association between prenatal PFAS exposure and earlier onset of AD in children in a 5-year follow-up study. From 2001 to 2005, 1264 mother-infant pairs were recruited from eight Taiwanese (...)
see on pubmed
Synthesis of chitosan derivatives with organoselenium and organosulfur compounds: Characterization, antimicrobial properties and application as biomaterials.
Carbohydr Polym.
2019 Sep 01, 219:240-250.
In this study, Schiff bases of chitosan (CS) were synthesized using citronellal, citral, and their derivatives containing selenium and sulfur. Organoselenium and organosulfur compounds show attractive biological and pharmaceutical activities, which can be beneficial to CS-based materials. From the characterization analyses, it was found that the CS-derivatives containing organoselenium and organosulfur compounds exhibited the highest conversion degrees (23 and 28%). Biological assays were (...)
see on pubmed
Effect of cinnamamides on atopic dermatitis through regulation of IL-4 in CD4 cells.
Choi EJ et al.
Effect of cinnamamides on atopic dermatitis through regulation of IL-4 in CD4 cells.
J Enzyme Inhib Med Chem.
2019 Dec , 34, (1):613-619.
This study aimed to evaluate the effects of cinnamamides on atopic dermatitis (AD) and the mechanisms underlying these effects. To this end, the actions of two cinnamamides, (E)-3-(4-hydroxyphenyl)-N-phenylethyl acrylamide (NCT) and N-trans-coumaroyltyramine (NCPA), were determined on AD by orally administering them to mice. Oral administration of the cinnamamides ameliorated the increase in epidermal and dermal thickness as well as mast cell infiltration. Cinnamamides suppressed serum (...)
see on pubmed
