[|Since psoriasis is a polygenic disease, it cannot be the outcome of a
single cell anomaly – again, here I disagree strongly.|auteur195]
[|I strongly support the statement "psoriasis
is the outcome of a skin cell anomaly". Indeed, we cannot consider psoriasis a
defect in one cell type. Although T-cells have received a lot of attention, it
is intriguing that anti-TNFa
treatments are more effective as compared to T-cell specific approaches. It is
the broad interaction of TNF-a which
proves to be essential for a substantial therapeutic effect, whilst T-cell
targeted treatments have a more modest efficacy.|auteur197]
It has been clearly demonstrated for over 30 years now, particularly by Gerald Krueger, that grafting lesional or non lesional psoriatic skin onto a nude mouse ends in maintaining a psoriatic phenotype in the form of persistent epidermal hyperproliferation, when comparing these grafts with normal skin grafts. This epidermal hyperproliferation is only produced if the dermis is also grafted, indicating that dermal cells are necessary for the expression of a psoriatic phenotype. More recently, it has been shown that activated T lymphocytes from a psoriasis plaque, when injected into a psoriatic skin grafted onto a nude mouse, led to the appearance of a clinical and histological psoriasis plaque. By contrast, injecting these same cells into normal skin grafted onto the nude mouse does not have this effect. The inflammatory cells, therefore, only cause psoriasis to appear if they encounter abnormal skin cells.
SPIN Presentation
Recent news
- 2019/10/29 Focus on...
- 2019/08/12 Focus on...
Latin American Clinical Practice Guidelines on the Systemic Treatment of Psoriasis
- 2019/06/03 Focus on...
- 2019/05/21 Focus on...
- 2019/04/18 Focus on...
News from the web office
- 2016/10/29
- 2016/05/26
- 2016/02/20
Events
- 2019/04/18 Focus on...
- 2018/02/21
News from medical groups
- 2018/04/18
- 2017/06/21
News from patients associations
- 2017/02/08
- 2016/05/26
Recent publications on Psoriasis and Atopic Dermatitis
on Psoriasis
In vitro evaluation of Naltrexone HCl 1% Topical Cream in XemaTop™ for psoriasis.
Ip K et al.
In vitro evaluation of Naltrexone HCl 1% Topical Cream in XemaTop™ for psoriasis.
Arch. Dermatol. Res..
2020 Mar , 312, (2):145-154.
Psoriasis is a multifactorial skin disease involving abnormal cell proliferation and inflammation; an efficacious topical treatment is yet to be identified. A formulation containing 1% Naltrexone HCl in XemaTop™ base was compounded, characterized and evaluated in vitro as a possible treatment for psoriasis. A three-dimensional psoriasis tissue model was exposed to the formulation for 2 or 5 days and analyzed for the level of markers of cellular proliferation, and inflammatory cytokine IL-6. (...)
see on pubmed
Hydrogen peroxide in neutrophil inflammation: Lesson from the zebrafish.
Martínez-Navarro FJ et al.
Hydrogen peroxide in neutrophil inflammation: Lesson from the zebrafish.
Dev. Comp. Immunol..
2020 Apr , 105:103583.
The zebrafish has become an excellent model for the study of inflammation and immunity. Its unique advantages for in vivo imaging and gene and drug screening have allowed the visualization of dual oxidase 1 (Duox1)-derived hydrogen peroxide (HO) tissue gradients and its crosstalk with neutrophil infiltration to inflamed tissue. Thus, it has been shown that HO directly recruits neutrophils via the Src-family tyrosine kinase Lyn and indirectly by the activation of several signaling pathways (...)
see on pubmed
IL-36α contributes to enhanced T helper 17 type responses in allergic rhinitis.
Qin X et al.
IL-36α contributes to enhanced T helper 17 type responses in allergic rhinitis.
Cytokine.
2020 Apr , 128:154992.
T helper 17 (Th17) cell subsets, belongs to CD4+ T cell lineage, are proved to be closely related to pathophysiology of AR recently. The interleukin-36 (IL-36) had been reported to promote the up-regulation of Th17 cytokines in psoriasis. We investigated the regulation of Th17 inflammation by IL-36 family cytokines in allergic rhinitis (AR).
see on pubmed
on Atopic Dermatitis
Atopic dermatitis induces anxiety- and depressive-like behaviors with concomitant neuronal adaptations in brain reward circuits in mice.
Prog. Neuropsychopharmacol. Biol. Psychiatry.
2020 Mar 02, 98:109818.
Clinically, it has been reported that atopic dermatitis (AD) has been linked with negative emotional problems such as depression and anxiety, thereby reducing the quality of life, but little is known about the molecular mechanism that underlies AD-associated emotional impairments. We sought to determine whether AD could induce anxiety- and depressive-like symptoms in mice and to identify pertinent signaling changes in brain reward circuitry. AD-like lesions were induced by the repeated (...)
see on pubmed
Efficacy and safety of indigo naturalis ointment in Treating Atopic Dermatitis: A randomized clinical trial.
J Ethnopharmacol.
2020 Mar 25, 250:112477.
Indigo naturalis, a herbal medicine with a history of use dating back to ancient times, may be a good alternative topical treatment for atopic dermatitis (AD).
see on pubmed
"Eczema" of the nape: A marker of pthiriasis capitis.
Veraldi S et al.
"Eczema" of the nape: A marker of pthiriasis capitis.
Parasitol. Int..
2020 Apr , 75:102026.
Pthirus pubis usually infests the pubis, inguinal folds, buttocks and perianal region. In hairy males or when the infestation is longstanding, this louse can also occur on the thighs, abdomen, chest, axillae and beard. Eyelashes may be involved in children. The involvement of the scalp is very rare. We describe four girls with P. pubis infestation located exclusively on the scalp which was characterized by a rash on the nape that can suggest a head and neck form of atopic (...)
see on pubmed
