[|Since psoriasis is a polygenic disease, it cannot be the outcome of a
single cell anomaly – again, here I disagree strongly.|auteur195]
[|I strongly support the statement "psoriasis
is the outcome of a skin cell anomaly". Indeed, we cannot consider psoriasis a
defect in one cell type. Although T-cells have received a lot of attention, it
is intriguing that anti-TNFa
treatments are more effective as compared to T-cell specific approaches. It is
the broad interaction of TNF-a which
proves to be essential for a substantial therapeutic effect, whilst T-cell
targeted treatments have a more modest efficacy.|auteur197]
It has been clearly demonstrated for over 30 years now, particularly by Gerald Krueger, that grafting lesional or non lesional psoriatic skin onto a nude mouse ends in maintaining a psoriatic phenotype in the form of persistent epidermal hyperproliferation, when comparing these grafts with normal skin grafts. This epidermal hyperproliferation is only produced if the dermis is also grafted, indicating that dermal cells are necessary for the expression of a psoriatic phenotype. More recently, it has been shown that activated T lymphocytes from a psoriasis plaque, when injected into a psoriatic skin grafted onto a nude mouse, led to the appearance of a clinical and histological psoriasis plaque. By contrast, injecting these same cells into normal skin grafted onto the nude mouse does not have this effect. The inflammatory cells, therefore, only cause psoriasis to appear if they encounter abnormal skin cells.
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Recent publications on Psoriasis and Atopic Dermatitis
on Psoriasis
Mimicking cigarette smoke exposure to assess cutaneous toxicity.
Prieux R et al.
Mimicking cigarette smoke exposure to assess cutaneous toxicity.
Toxicol In Vitro.
2020 Feb , 62:104664.
Cigarette smoke stands among the most toxic environmental pollutants and is composed of thousands of chemicals including polycyclic aromatic hydrocarbons (PAHs). Despite restrict cigarette smoking ban in indoor or some outdoor locations, the risk of non-smokers to be exposed to environmental cigarette smoke is not yet eliminated. Beside the well-known effects of cigarette smoke to the respiratory and cardiovascular systems, a growing literature has shown during the last 3 decades its (...)
see on pubmed
Penta-O-galloyl-β-D-glucose from Paeonia lactiflora Pall. root extract enhances the expression of skin barrier genes via EGR3.
J Ethnopharmacol.
2020 Feb 10, 248:112337.
Paeonia lactiflora Pall. has long been used to treat inflammatory skin diseases, such as psoriasis.
see on pubmed
CARD14/CARMA2sh and TANK differentially regulate poly(I:C)-induced inflammatory reaction in keratinocytes.
J. Cell. Physiol..
2020 Mar , 235, (3):1895-1902.
CARD14/CARMA2sh (CARMA2sh) is a scaffold protein whose mutations are associated with the onset of human genetic psoriasis and other inflammatory skin disorders. Here we show that the immunomodulatory adapter protein TRAF family member-associated NF-κB activator (TANK) forms a complex with CARMA2sh and MALT1 in a human keratinocytic cell line. We also show that CARMA2 and TANK are individually required to activate the nuclear factor κB (NF-κB) response following exposure to (...)
see on pubmed
on Atopic Dermatitis
Mimicking cigarette smoke exposure to assess cutaneous toxicity.
Prieux R et al.
Mimicking cigarette smoke exposure to assess cutaneous toxicity.
Toxicol In Vitro.
2020 Feb , 62:104664.
Cigarette smoke stands among the most toxic environmental pollutants and is composed of thousands of chemicals including polycyclic aromatic hydrocarbons (PAHs). Despite restrict cigarette smoking ban in indoor or some outdoor locations, the risk of non-smokers to be exposed to environmental cigarette smoke is not yet eliminated. Beside the well-known effects of cigarette smoke to the respiratory and cardiovascular systems, a growing literature has shown during the last 3 decades its (...)
see on pubmed
Sublingual Immunotherapy for Other Indications: Venom Large Local, Latex, Atopic Dermatitis, and Food.
Immunol Allergy Clin North Am.
2020 Feb , 40, (1):41-57.
There is some evidence to support the use of sublingual immunotherapy (SLIT) in food allergy, although its role is unclear. One randomized, double-blind, placebo-controlled trial supports the safe and efficacious use of dust mite SLIT in children with mild to moderate atopic dermatitis, but these data have not been confirmed. Although there are several randomized, double-blind, placebo-controlled trials to support the use of SLIT-LATEX, this product is not available in the United States and (...)
see on pubmed
The Cost-Effectiveness of Allergen Immunotherapy Compared with Pharmacotherapy for Treatment of Allergic Rhinitis and Asthma.
Immunol Allergy Clin North Am.
2020 Feb , 40, (1):69-85.
This article evaluates the cost-effectiveness of allergy immunotherapy (AIT) in the treatment of allergic rhinitis, asthma, and other allergic conditions. An extensive search of the PubMed and Medline databases (up to December 2018) was conducted. There is strong evidence in the collective literature, which included individual studies and systematic reviews, that AIT is cost-effective in the management of allergic rhinitis and asthma as compared with standard drug treatment alone. The (...)
see on pubmed
