Eye disorders in Atopic Dermatitis
"Eye disorders in Atopic Dermatitis" takes part of the Fundamentals programme 2025.
The intervention has been prepared by Dr Roselie Achten (University Medical Center,Utrecht, The Netherlands).
Atopic dermatitis (AD) is a chronic inflammatory skin condition for which new targeted therapies are available, such as biologics. Increased rates of ocular surface disease (OSD) have been reported during treatment with biologics, necessitating better understanding of its occurrence and mechanisms. Many patients with moderate-to-severe AD already show signs of OSD before starting biologic treatment, though not all report symptoms. OSD in moderate-to-severe AD is associated with fewer conjunctival goblet cells, higher disease activity, facial/eyelid eczema, and elevated tear biomarkers. The e-learning also discusses dupilumab-associated OSD (DAOSD), which occurs in about one-third of dupilumab-treated AD patients. Anti-inflammatory ophthalmological treatments and dupilumab dose reduction may lead to improvement of DAOSD. Though the exact mechanism is unclear, reduced Mucin 5AC expression suggests an impairment of the goblet cell function by dupilumab. Higher dupilumab levels in tear fluid (but not serum) are observed in patients with more severe OSD.
Clinicians should be aware of the high rates of OSD in moderate-to-severe AD patients, both before and during biologic treatment, and should refer patients to ophthalmologists when needed.
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