[|I absolutely agree with the
statement of the value of biopsies in psoriasis.|auteur195]
[|However, the classical histopathological picture as described in the
chapter on histopathology is seen only in a minority of the biopsies taken from the psoriatic
plaque. In particular, the Munro micro abscesses and micro pustules of
kogoj can be difficult to find. Acute psoriatic papules and the margin zone of
spreading psoriatic plaques more frequently show the complete histopathological
picture as described above. Therefore, for diagnostic purposes biopsies have to
be taken from the margin zone or from psoriatic papules.|auteur197]
[|The eight major characteristics, together with micrographs, are well-described. In addition to the difficulty in distinguishing psoriasis from eczema on the palms and soles, I also do feel that erythrodermic psoriasis, with or without pustulation, also is frequently non-specific with overlap features between eczema and psoriasis. Certainly, I believe that immunohistochemistry may frequently be of more value in distinguishing psoriasis from its clinical and histological “look alikes”, eg eczema, cutaneous T-cell lymphoma, etc.|auteur215]
The typical histological appearance of psoriasis is well known (photo 40). It is characterized by:
- parakeratosis,
- presence of Munro microabscesses (photos 41 and 42),
- absence of a granular layer except on the nail, where conversely hypergranulosis exists,
- epidermal acanthosis pertaining solely to the interpapillary (rete) ridges,
- elongation and edema of the dermal papillae,
- thinning of the superjacent malpighian stratum,
- increase in the number of mitoses,
- major proliferation of the endothelial cells with hypertrophy and vasodilatation of the papillary capillarie
Pustular psoriasis is characterized by subcorneal multilocular pustules.
This typical histological appearance will only be found in clinically typical lesions (photo 43). When it comes to the palms of the hands and the soles of the feet, a spongiosis is practically always observed. Histological examination will not allow eczema to be differentiated from psoriasis in these localisations.
Thus, histological examination in psoriasis is only useful in two contexts: for securing histological evidence in an illness whose management will be reflected over the long term, and for ruling out other illnesses: parapsoriasis en plaque, lichen and so on.
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Recent publications on Psoriasis and Atopic Dermatitis
on Psoriasis
Uncovering the mechanism of Jueyin granules in the treatment of psoriasis using network pharmacology.
J Ethnopharmacol.
2020 Nov 15, 262:113214.
Our clinical practice demonstrated that Jueyin granules (JYG) benefit patients with mild to moderate psoriasis vulgaris without apparent adverse effects. JYG have been shown to inhibit epidermal proliferation in an imiquimod (IMQ)-induced psoriasis-like mouse model, as well as keratinocyte proliferation. Moreover, JYG causes no acute or chronic toxicity in animal models. However, its related molecular mechanism has still not been (...)
see on pubmed
Tackling the various classes of nano-therapeutics employed in topical therapy of psoriasis.
Drug Deliv.
2020 Dec , 27, (1):662-680.
Psoriasis is a dermatological chronic skin condition with underlying autoimmune etiology. It deeply affects patients' quality of life. Therefore, it was an interesting target for researchers throughout the past years. Conventionally, the treatment options include anti-inflammatory agents, immune suppressants, biologic treatment, and phototherapy. Nanotechnology offers promising characteristics that allow for tailoring a drug carrier to achieve dermal targeting, improved efficacy and (...)
see on pubmed
In silico data mining of large-scale databases for the virtual screening of human interleukin-2 inhibitors.
Acta Pharm.
2021 Mar 01, 71, (1):33-56.
Interleukin-2 (IL-2) is involved in the activation and differentiation of T-helper cells. Uncontrolled activated T cells play a key role in the pathophysiology by stimulating inflammation and autoimmune diseases like arthritis, psoriasis and Crohn's disease. T cells activation can be suppressed either by preventing IL-2 production or blocking the IL-2 interaction with its receptor. Hence, IL-2 is now emerging as a target for novel therapeutic approaches in several autoimmune disorders. This (...)
see on pubmed
on Atopic Dermatitis
Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps.
Allergy Asthma Immunol Res.
2020 Nov , 12, (6):980-993.
Recent studies have revealed the pathogenic role of interleukin (IL)-22 in atopic dermatitis and asthma. However, little is known about the role of IL-22 in the pathophysiology of chronic rhinosinusitis with nasal polyps. We aimed to investigate the expression of IL-22 and its pathogenic function in type 2 immune reactions of nasal polyps (NP).
see on pubmed
Facial Redness in Atopic Dermatitis Patients Treated With Dupilumab: A Case Series.
Seok SH et al.
Facial Redness in Atopic Dermatitis Patients Treated With Dupilumab: A Case Series.
Allergy Asthma Immunol Res.
2020 Nov , 12, (6):1063-1065.
Update on canine filaggrin: a review.
Combarros D et al.
Update on canine filaggrin: a review.
Vet Q.
2020 Dec , 40, (1):162-168.
Human filaggrin (FLG) plays a key role in epidermal barrier function, and loss-of-function mutations of its gene are primarily responsible for the development of human atopic dermatitis (AD). FLG expression is also reduced in the epidermis of atopic patients, due to the transcriptional effect of Th2 type cytokines. Canine atopic dermatitis (CAD) is a prevalent skin disease that shares many clinical and pathogenic features with its human homologue. The aim of this review is discuss current (...)
see on pubmed
