[|I absolutely agree with the
statement of the value of biopsies in psoriasis.|auteur195]
[|However, the classical histopathological picture as described in the
chapter on histopathology is seen only in a minority of the biopsies taken from the psoriatic
plaque. In particular, the Munro micro abscesses and micro pustules of
kogoj can be difficult to find. Acute psoriatic papules and the margin zone of
spreading psoriatic plaques more frequently show the complete histopathological
picture as described above. Therefore, for diagnostic purposes biopsies have to
be taken from the margin zone or from psoriatic papules.|auteur197]
[|The eight major characteristics, together with micrographs, are well-described. In addition to the difficulty in distinguishing psoriasis from eczema on the palms and soles, I also do feel that erythrodermic psoriasis, with or without pustulation, also is frequently non-specific with overlap features between eczema and psoriasis. Certainly, I believe that immunohistochemistry may frequently be of more value in distinguishing psoriasis from its clinical and histological “look alikes”, eg eczema, cutaneous T-cell lymphoma, etc.|auteur215]
The typical histological appearance of psoriasis is well known (photo 40). It is characterized by:
- parakeratosis,
- presence of Munro microabscesses (photos 41 and 42),
- absence of a granular layer except on the nail, where conversely hypergranulosis exists,
- epidermal acanthosis pertaining solely to the interpapillary (rete) ridges,
- elongation and edema of the dermal papillae,
- thinning of the superjacent malpighian stratum,
- increase in the number of mitoses,
- major proliferation of the endothelial cells with hypertrophy and vasodilatation of the papillary capillarie
Pustular psoriasis is characterized by subcorneal multilocular pustules.
This typical histological appearance will only be found in clinically typical lesions (photo 43). When it comes to the palms of the hands and the soles of the feet, a spongiosis is practically always observed. Histological examination will not allow eczema to be differentiated from psoriasis in these localisations.
Thus, histological examination in psoriasis is only useful in two contexts: for securing histological evidence in an illness whose management will be reflected over the long term, and for ruling out other illnesses: parapsoriasis en plaque, lichen and so on.
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Recent publications on Psoriasis and Atopic Dermatitis
on Psoriasis
Integrated analysis of gene expression profiles identifies transcription factors potentially involved in psoriasis pathogenesis.
J. Cell. Biochem..
2019 Aug , 120, (8):12582-12594.
Psoriasis is a common inflammatory skin disease mediated by cells and molecules in both the innate and adaptive immune systems. Recently, gene expression profile analysis revealed a large set of immune-related differentially expressed genes (DEGs) in psoriasis. However, the associations between these DEGs and their transcriptional regulation mechanisms have not been completely elucidated. In this study, several psoriasis Gene Expression Omnibus data sets were systematically analyzed using (...)
see on pubmed
Models of human psoriasis: Zebrafish the newly appointed player.
Martínez-Navarro FJ et al.
Models of human psoriasis: Zebrafish the newly appointed player.
Dev. Comp. Immunol..
2019 Aug , 97:76-87.
Psoriasis is a human chronic, immune disease with severe cutaneous and systemic manifestations. Its prevalence, among the world population, highly varies with ethnicity and geography, but not sex from remarkable low levels in Asia to 2.3% in Spain, or an impressive 11.5% in Norway. The pathogenesis of psoriasis derives from complex genetic and environmental interactions, which creates aberrant crosstalk between keratinocytes and variated immune cell, resulting in open amplified inflammatory (...)
see on pubmed
A vivid cytokines interaction model on psoriasis with the effect of impulse biologic (TNF-α inhibitor) therapy.
J. Theor. Biol..
2019 Aug 07, 474:63-77.
Psoriasis is a chronic skin condition that produces plaques of condensed, scaling skin due to excessively rapid proliferation of keratinocytes. During the disease progression, keratinocyte proliferation is influenced by many immune cells and cytokines. This article deals with a five dimensional deterministic model, which has been derived using quasi-steady-state approximation for describing the dynamics of psoriasis in various cytokines environment. Equilibrium analysis of the system shows (...)
see on pubmed
on Atopic Dermatitis
Prenatal perfluorooctanoic acid exposure is associated with early onset atopic dermatitis in 5-year-old children.
Chemosphere.
2019 Sep , 231:25-31.
Atopic dermatitis (AD) is the most common childhood skin disease and the first step of atopic march. Perfluoroalkyl substance (PFAS) exposure is associated with atopic diseases, including AD. However, whether PFAS exposure is related to earlier AD onset remains unclear. We aimed to investigate the association between prenatal PFAS exposure and earlier onset of AD in children in a 5-year follow-up study. From 2001 to 2005, 1264 mother-infant pairs were recruited from eight Taiwanese (...)
see on pubmed
Synthesis of chitosan derivatives with organoselenium and organosulfur compounds: Characterization, antimicrobial properties and application as biomaterials.
Carbohydr Polym.
2019 Sep 01, 219:240-250.
In this study, Schiff bases of chitosan (CS) were synthesized using citronellal, citral, and their derivatives containing selenium and sulfur. Organoselenium and organosulfur compounds show attractive biological and pharmaceutical activities, which can be beneficial to CS-based materials. From the characterization analyses, it was found that the CS-derivatives containing organoselenium and organosulfur compounds exhibited the highest conversion degrees (23 and 28%). Biological assays were (...)
see on pubmed
Effect of cinnamamides on atopic dermatitis through regulation of IL-4 in CD4 cells.
Choi EJ et al.
Effect of cinnamamides on atopic dermatitis through regulation of IL-4 in CD4 cells.
J Enzyme Inhib Med Chem.
2019 Dec , 34, (1):613-619.
This study aimed to evaluate the effects of cinnamamides on atopic dermatitis (AD) and the mechanisms underlying these effects. To this end, the actions of two cinnamamides, (E)-3-(4-hydroxyphenyl)-N-phenylethyl acrylamide (NCT) and N-trans-coumaroyltyramine (NCPA), were determined on AD by orally administering them to mice. Oral administration of the cinnamamides ameliorated the increase in epidermal and dermal thickness as well as mast cell infiltration. Cinnamamides suppressed serum (...)
see on pubmed
