Le professeur Louis Dubertret, ex-président de la fondation René Touraine, nous explique les fausses opinions qu’accompagnent souvent un individu atteint par la maladie.
Le psoriasis est-il contagieux ?
Non. Vous pouvez, par exemple, aller à la piscine avec du psoriasis sans aucun risque. Au contraire, la peau psoriasique, avec ses plaques, contient bien plus de molécules anti-infectieuses qu’une peau normale. Il s’agit donc d’une peau qui s’infecte beaucoup moins qu’une autre.
Le psoriasis est-il héréditaire ?
Ce question est récurrente car le psoriasis a une origine génétique. Cependant, cette transmission se réalise non pas de manière mathématique ou monogénique, mais bien comme un "terrain" favorable aux membres d’une même famille. De la même manière qu’une mère atteinte régulièrement de rhumes des foins a des enfants qui présentent le risque de le développer, un parent atteint de psoriasis aura des enfants risquant de developper cette pathologie plus que la moyenne. Cette inquiétude se retrouve souvent chez un futur parent souffrant de psoriasis sévère. Mais il faut savoir que dans ce cas-là, le mélange de ses gènes avec ceux de l’autre parent ne peut, au pire, qu’entraîner un psoriasis plus modéré chez l’enfant. Aussi, le développement de traitements de plus en plus efficaces doit nous faire sortir de la vision du psoriasis comme une malédiction transmise de génération en génération.
Si mon traitement ne me convient pas, dois-je changer de médecin ?
En raison de ses symptômes variables pour chaque individu, le psoriasis fait partie de ces maladies où le patient dispose d’informations précieuses sur sa condition que le médecin ne peut connaître. De ce fait, le patient doit les lui communiquer régulièrement afin de bénéficier d’un ajustement continu de son traitement permettant de l’améliorer dans le temps. Changer perpétuellement de médecin est donc une erreur puisque cela compromet l’efficacité des soins. Il vaut donc mieux avoir la patience d’expliquer à son médecin de départ les causes de son insatisfaction afin que ce dernier, essai après essai, trouve le traitement idéal. Cela est d’autant plus important qu’aucun médecin ne peut tout savoir, surtout dans le cas d’une maladie s’exprimant différemment chez chaque personne.
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Recent publications on Psoriasis and Atopic Dermatitis
on Psoriasis
Screening for cardiovascular comorbidity in United States outpatients with psoriasis, hidradenitis, and atopic dermatitis.
Arch Dermatol Res.
2021 Apr , 313, (3):163-171.
Psoriasis, hidradenitis, and atopic dermatitis (AD) are associated with increased cardiometabolic comorbidities. Yet, little is known about screening rates for cardiometabolic comorbidities in patients with these disorders. The objective of this study is to determine rates and predictors of cardiovascular screening among patients with psoriasis, AD, and hidradenitis in the United States. Data from the 2006-2015 National Ambulatory Medical Care Survey were analyzed, including 67,581 (...)
see on pubmed
Nanoliposomes@Transcutol for Skin Delivery of 8-Methoxypsoralen.
Sinico C et al.
Nanoliposomes@Transcutol for Skin Delivery of 8-Methoxypsoralen.
J Nanosci Nanotechnol.
2021 May 01, 21, (5):2901-2906.
8-methoxypsoralen is the most common drug in psoralen plus ultraviolet light irradiation therapy for the treatment of severe psoriasis. Despite of the efficacy, its classic oral administration leads to several serious adverse effects. However, the topical psoralen application produces a drug skin accumulation lower than that obtained by oral administration, due to the drug low skin permeability. In this paper, 8-methoxypsoralen loaded Penetration Enhancer-containing Vesicles were prepared (...)
see on pubmed
Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways.
Bioengineered.
2021 Dec , 12, (1):183-195.
Psoriasis is a chronic inflammatory skin disease that affects approximately 2% of worldwide population, and causing long-term troubles to the patients. Therefore, it is urgent to develop safe and effective therapeutic drugs. Catalpol is a natural iridoid glucoside, that has several remarkable pharmacological effects, however, whether catalpol can alleviated psoriasis has not been explored. The goal of the present work is to study the role of catalpol in psoriasis in vivo and in vitro. (...)
see on pubmed
on Atopic Dermatitis
Screening for cardiovascular comorbidity in United States outpatients with psoriasis, hidradenitis, and atopic dermatitis.
Arch Dermatol Res.
2021 Apr , 313, (3):163-171.
Psoriasis, hidradenitis, and atopic dermatitis (AD) are associated with increased cardiometabolic comorbidities. Yet, little is known about screening rates for cardiometabolic comorbidities in patients with these disorders. The objective of this study is to determine rates and predictors of cardiovascular screening among patients with psoriasis, AD, and hidradenitis in the United States. Data from the 2006-2015 National Ambulatory Medical Care Survey were analyzed, including 67,581 (...)
see on pubmed
Qingxue jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-κB signaling pathways.
J Ethnopharmacol.
2021 Apr 24, 270:113773.
Qingxue jiedu Formulation (QF) is composed of two classic prescriptions which have been clinically used for more than 5 centuries and appropriately modified through basic theory of traditional Chinese medicine for treating various skin inflammation such as atopic dermatitis (AD), acute dermatitis and rash. Although QF possesses a prominent clinical therapeutic effect, seldom pharmacological studies on its anti-AD activity are (...)
see on pubmed
Methicillin-resistant from infected skin lesions present several virulence genes and are associated with the CC30 in Brazilian children with atopic dermatitis.
Virulence.
2021 Dec , 12, (1):260-269.
Atopic dermatitis (AD) is a chronic inflammatory skin disease and colonization by may affect up to 100% of these patients. Virulent and resistant isolates can worsen AD patient clinical condition and jeopardize the treatment. We aimed to detect virulence genes and to evaluate the biofilm production of isolates from infected skin lesions of children with AD. Methicillin resistance was detected by phenotypic and molecular tests and the virulence genes were detected by PCR. Biofilm formation (...)
see on pubmed
